Comparison of Molecular, Clinicopathological, and Pedigree Differences Between Lynch-Like and Lynch Syndromes

Clinicopathological Features and Management of Cancers in Lynch Syndrome

Lynch syndrome (LS) is characterized by an autosomal dominant inheritance of the early onset of colorectal cancer (CRC) and endometrial cancer, as well as increased risk for several other cancers including gastric, urinary tract, ovarian, small bowel, biliary tract, and brain tumors. The syndrome is due to a mutation in one of the four DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2. ...

Association between Lynch syndrome and renal carcinoma.

We read with interest the study published by Ferrer et al. about a patient with Lynch syndrome (LS) who presented a colorectal carcinoma (CRC) and a synchronous clear cell renal carcinoma (CCRC) (1). From our point of view, it would be interesting to emphasize some aspects of this patient, such as the type of mutation carried by the patient, and its cancer familial tree. In addition, we would l...

Genetic Testing for Lynch Syndrome and Inherited Intestinal Polyposis Syndromes

When Policy Topic is covered Genetic testing for APC gene mutations may be considered medically necessary in the following patients:  At-risk relatives (see Considerations) of patients with FAP and/or a known APC mutation.  Patients with a differential diagnosis of attenuated FAP vs. MYH-associated polyposis vs. Lynch syndrome. Whether testing begins with APC mutations or screening for MMR mu...

G Lynch

meant by "more effective." This unqualified assertion is likely to confuse the many people who already use or recommend All-Bran as an "effective" means of avoiding constipation whatever its soluble:insoluble fibre ratio or influence on plasma lipids, mineral absorption, faecal bulking, bowel transit time, etc. Furthermore, it is difficult to see why "wholemeal bread and crispbreads" are the on...

Sean Lynch ,